Recruitment and retention of persons participating in research is one of the most significant challenges faced by investigators. Evidence-based approaches to promoting subject retention include supporting and educating research nurses, providing empathy and respect, including patients in decisions, negotiating with visitors, alleviating symptoms, and supporting a plan of care consistent with both the research protocol and the patient’s recovery.

While providing a similar approach to all groups, experimental researchers in a variable clinical environment must also provide some individualization and communication to retain valuable subjects who are ill.